WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=26; E=0.80; R=32.52; rawP=1.04e-31; adjP=4.06e-30
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109332 NA UBE2D3 ubiquitin-conjugating enzyme E2D 3 7323 ENSG00000109332
2  ENSG00000120694 NA HSPH1 heat shock 105kDa/110kDa protein 1 10808 ENSG00000120694
3  ENSG00000166598 NA HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 7184 ENSG00000166598
4  ENSG00000197930 NA ERO1L ERO1-like (S. cerevisiae) 30001 ENSG00000197930
5  ENSG00000109971 NA HSPA8 heat shock 70kDa protein 8 3312 ENSG00000109971
6  ENSG00000044574 NA HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3309 ENSG00000044574
7  ENSG00000149428 NA HYOU1 hypoxia up-regulated 1 10525 ENSG00000149428
8  ENSG00000167004 NA PDIA3 protein disulfide isomerase family A, member 3 2923 ENSG00000167004
9  ENSG00000090520 NA DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 51726 ENSG00000090520
10  ENSG00000131871 NA VIMP VCP-interacting membrane protein 55829 ENSG00000131871
11  ENSG00000132002 NA DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3337 ENSG00000132002
12  ENSG00000086061 NA DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 3301 ENSG00000086061
13  ENSG00000112208 NA BAG2 BCL2-associated athanogene 2 9532 ENSG00000112208
14  ENSG00000204388 NA HSPA1B heat shock 70kDa protein 1B 3304 ENSG00000204388
15  ENSG00000136986 NA DERL1 derlin 1 79139 ENSG00000136986
16  ENSG00000179218 NA CALR calreticulin 811 ENSG00000179218
17  ENSG00000163902 NA RPN1 ribophorin I 6184 ENSG00000163902
18  ENSG00000079332 NA SAR1A SAR1 homolog A (S. cerevisiae) 56681 ENSG00000079332
19  ENSG00000136770 NA DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 64215 ENSG00000136770
20  ENSG00000134910 NA STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 3703 ENSG00000134910
21  ENSG00000129562 NA DAD1 defender against cell death 1 1603 ENSG00000129562
22  ENSG00000100219 NA XBP1 X-box binding protein 1 7494 ENSG00000100219
23  ENSG00000118705 NA RPN2 ribophorin II 6185 ENSG00000118705
24  ENSG00000080824 NA HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 3320 ENSG00000080824
25  ENSG00000143870 NA PDIA6 protein disulfide isomerase family A, member 6 10130 ENSG00000143870
26  ENSG00000151092 NA NGLY1 N-glycanase 1 55768 ENSG00000151092


Database:KEGG pathway       Name:Antigen processing and presentation       ID:04612
C=76; O=7; E=0.37; R=19.01; rawP=9.35e-08; adjP=1.82e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000179218 NA CALR calreticulin 811 ENSG00000179218
2  ENSG00000167004 NA PDIA3 protein disulfide isomerase family A, member 3 2923 ENSG00000167004
3  ENSG00000080824 NA HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 3320 ENSG00000080824
4  ENSG00000131467 NA PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 10197 ENSG00000131467
5  ENSG00000109971 NA HSPA8 heat shock 70kDa protein 8 3312 ENSG00000109971
6  ENSG00000044574 NA HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3309 ENSG00000044574
7  ENSG00000204388 NA HSPA1B heat shock 70kDa protein 1B 3304 ENSG00000204388


Database:KEGG pathway       Name:N-Glycan biosynthesis       ID:00510
C=49; O=6; E=0.24; R=25.27; rawP=1.42e-07; adjP=1.85e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163902 NA RPN1 ribophorin I 6184 ENSG00000163902
2  ENSG00000118705 NA RPN2 ribophorin II 6185 ENSG00000118705
3  ENSG00000158850 NA B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 8703 ENSG00000158850
4  ENSG00000134910 NA STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 3703 ENSG00000134910
5  ENSG00000129562 NA DAD1 defender against cell death 1 1603 ENSG00000129562
6  ENSG00000159063 NA ALG8 asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) 79053 ENSG00000159063


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=7; E=0.73; R=9.57; rawP=9.71e-06; adjP=9.47e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152147 NA GEMIN6 gem (nuclear organelle) associated protein 6 79833 ENSG00000152147
2  ENSG00000125977 NA EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 8894 ENSG00000125977
3  ENSG00000132341 NA RAN RAN, member RAS oncogene family 5901 ENSG00000132341
4  ENSG00000151247 NA EIF4E eukaryotic translation initiation factor 4E 1977 ENSG00000151247
5  ENSG00000104131 NA EIF3J eukaryotic translation initiation factor 3, subunit J 8669 ENSG00000104131
6  ENSG00000023734 NA STRAP serine/threonine kinase receptor associated protein 11171 ENSG00000023734
7  ENSG00000163002 NA NUP35 nucleoporin 35kDa 129401 ENSG00000163002


Database:KEGG pathway       Name:Protein export       ID:03060
C=23; O=3; E=0.11; R=26.92; rawP=0.0002; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144867 NA SRPRB signal recognition particle receptor, B subunit 58477 ENSG00000144867
2  ENSG00000118363 NA SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 9789 ENSG00000118363
3  ENSG00000044574 NA HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3309 ENSG00000044574


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=15; E=5.48; R=2.74; rawP=0.0004; adjP=0.0026
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000081181 NA ARG2 arginase, type II 384 ENSG00000081181
2  ENSG00000163902 NA RPN1 ribophorin I 6184 ENSG00000163902
3  ENSG00000004455 NA AK2 adenylate kinase 2 204 ENSG00000004455
4  ENSG00000135002 NA RFK riboflavin kinase 55312 ENSG00000135002
5  ENSG00000169764 NA UGP2 UDP-glucose pyrophosphorylase 2 7360 ENSG00000169764
6  ENSG00000134910 NA STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 3703 ENSG00000134910
7  ENSG00000129562 NA DAD1 defender against cell death 1 1603 ENSG00000129562
8  ENSG00000037757 NA MRI1 methylthioribose-1-phosphate isomerase homolog (S. cerevisiae) 84245 ENSG00000037757
9  ENSG00000159063 NA ALG8 asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) 79053 ENSG00000159063
10  ENSG00000088305 NA DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1789 ENSG00000088305
11  ENSG00000149476 NA DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae) 26007 ENSG00000149476
12  ENSG00000122884 NA P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 5033 ENSG00000122884
13  ENSG00000118705 NA RPN2 ribophorin II 6185 ENSG00000118705
14  ENSG00000158850 NA B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 8703 ENSG00000158850
15  ENSG00000152904 NA GGPS1 geranylgeranyl diphosphate synthase 1 9453 ENSG00000152904


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=5; E=0.65; R=7.64; rawP=0.0005; adjP=0.0028
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000143207 NA RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase 64326 ENSG00000143207
2  ENSG00000109332 NA UBE2D3 ubiquitin-conjugating enzyme E2D 3 7323 ENSG00000109332
3  ENSG00000148634 NA HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 26091 ENSG00000148634
4  ENSG00000176386 NA CDC26 cell division cycle 26 homolog (S. cerevisiae) 246184 ENSG00000176386
5  ENSG00000182179 NA UBA7 ubiquitin-like modifier activating enzyme 7 7318 ENSG00000182179


Database:KEGG pathway       Name:Ribosome biogenesis in eukaryotes       ID:03008
C=80; O=4; E=0.39; R=10.32; rawP=0.0006; adjP=0.0029
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000108651 NA UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 55813 ENSG00000108651
2  ENSG00000132341 NA RAN RAN, member RAS oncogene family 5901 ENSG00000132341
3  ENSG00000130826 NA DKC1 dyskeratosis congenita 1, dyskerin 1736 ENSG00000130826
4  ENSG00000107937 NA GTPBP4 GTP binding protein 4 23560 ENSG00000107937


Database:KEGG pathway       Name:Prion diseases       ID:05020
C=35; O=3; E=0.17; R=17.69; rawP=0.0007; adjP=0.0030
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000168439 NA STIP1 stress-induced-phosphoprotein 1 10963 ENSG00000168439
2  ENSG00000044574 NA HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3309 ENSG00000044574
3  ENSG00000169032 NA MAP2K1 mitogen-activated protein kinase kinase 1 5604 ENSG00000169032


Database:KEGG pathway       Name:Oocyte meiosis       ID:04114
C=112; O=4; E=0.54; R=7.37; rawP=0.0022; adjP=0.0086
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000066027 NA PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 5525 ENSG00000066027
2  ENSG00000176386 NA CDC26 cell division cycle 26 homolog (S. cerevisiae) 246184 ENSG00000176386
3  ENSG00000170027 NA YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 7532 ENSG00000170027
4  ENSG00000169032 NA MAP2K1 mitogen-activated protein kinase kinase 1 5604 ENSG00000169032




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).